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目的探讨口腔颌面部鳞癌患者术后病原菌感染情况及其对机体炎性因子水平的影响。方法选取2015年1月至2016年9月间重庆三峡中心医院收治的138例行手术治疗的口腔颌面部鳞癌患者,根据术后感染情况将患者分为A组(术后感染者)90例和B组(术后未感染者)48例两组。另选取接受健康体检的50例健康者为对照组。比较三组人员病原菌分布情况及炎性因子水平变化情况。结果 A组患者中有90株病原菌被分离,其中革兰阴性菌37株,革兰阳性菌53株。A、B两组患者血清白介素细胞-1(IL-1)、白介素细胞-2(IL-2)、白介素细胞-6(IL-6)、白介素细胞-10(IL-10)、肿瘤坏死因子-α(TNF-α)、转化生长因子-β(TNF-β)和干扰素-γ(INF-γ)水平,均显著高于对照组,差异均有统计学意义(均P<0.05),且A组患者上升幅度较B组更明显(P<0.05)。结论口腔颌面部鳞癌术后感染病原菌主要为革兰阳性菌,且此类患者感染后机体内血清炎性因子浓度大幅上升。
Objective To investigate the postoperative infection of pathogenic bacteria in oral and maxillofacial squamous cell carcinoma and its effect on inflammatory cytokines. Methods One hundred and thirty-eight patients with squamous cell carcinoma of oral and maxillofacial region who underwent surgery in Chongqing Three Gorges Central Hospital from January 2015 to September 2016 were selected and divided into group A (patients with postoperative infection) 90 according to postoperative infection Cases and B group (postoperative non-infected) 48 patients in two groups. The other 50 healthy people who took the physical examination were selected as the control group. The distribution of pathogenic bacteria and the changes of inflammatory cytokines in three groups were compared. Results A group of 90 patients were isolated from pathogens, including 37 gram-negative bacteria, 53 gram-positive bacteria. Serum interleukin-1, interleukin-2, interleukin-6, interleukin-10, tumor necrosis factor-alpha and interleukin- The levels of TNF-α, TNF-β and INF-γ were significantly higher than those of the control group (all P <0.05) The increase in group A was more significant than that in group B (P <0.05). Conclusion The pathogen of postoperative infection of oral and maxillofacial squamous cell carcinoma is Gram-positive bacteria, and the concentration of serum inflammatory cytokines in the patients after the infection is significantly increased.