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喉癌作为恶性实体肿瘤，化学药物疗法在其综合治疗中扮演着日益重要的角色，但多药耐药（M DR）的产生成为导致化疗失败的主要原因。研究表明，多药耐药基因蛋白 P-gp 和 ABCG2在喉癌的 M DR 中起着重要作用， P-gp 和 ABCG2之间或正或负呈相关性，其相关信号通路（MAPK）与 P-gp 和 ABCG2在肿瘤中的表达也有一定的相关性，但其调控因素及如何由此提高化疗效果有待进一步研究。“,”Laryngocatcinoma is a type of malignant solid tumor,and chemotherapy plays an increasingly important role in its treatment,but multidrug resistance (M DR)has become the leading cause of chemotherapy failure.Researches have showed that P-gp and ABCG2 proteins are important in the M DR of laryngocatcinoma,P-gp may be positively or negatively correlated with ABCG2,and their related signal pathways (MAPK)are related to their expressions in tumors. However,how P-gp and ABCG2 are controlled and how to improve the effect of chemotherapy remain to be further investigated.