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目的:比较狭窄冠状动脉导致心肌缺血模型犬在麻醉和清醒状态下的差异,及药物治疗的差异。方法:在无菌条件下给犬心外膜安置心电电极、血压导管、信号发射器并分离冠状动脉前降支,放置动脉压迫环。手术恢复期后,动物按正交设计给予处置:分别在清醒与麻醉状态下狭窄冠状动脉,进行模型组和硝酸甘油治疗组的观察。主要监测心外膜心电图ST段、血压、心率、体温。结果与结论:麻醉犬心率明显高于清醒犬,冠脉狭窄后麻醉及清醒犬心电图ST段均明显升高;硝酸甘油治疗的效果,清醒犬较麻醉犬起效快,维持时间长。
OBJECTIVE: To compare the difference between anesthetized and awake dogs with myocardial ischemia caused by stenosis coronary artery and the difference of drug treatment. Methods: The auricular electrode, blood pressure catheter and signal transmitter were placed on the epicardium of dog under aseptic conditions and the anterior descending coronary artery was separated and placed on the arterial compression ring. After surgery, the animals were treated in orthogonal design: stenosis of the coronary arteries under awake and anesthetized conditions, respectively, and model and nitroglycerin-treated groups were observed. The main monitoring epicardial electrocardiogram ST segment, blood pressure, heart rate, body temperature. RESULTS AND CONCLUSION: The heart rate of anesthetized dogs was significantly higher than that of awake dogs. After coronary stenosis, the ST segment of anesthetized and awake dogs was significantly increased. The effect of nitroglycerin treatment was faster and longer in awake dogs than in anesthetized dogs.