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目的探讨不同表型支气管哮喘患者血清、诱导痰中血管内皮生长因子(VEGF)、血小板衍生生长因子(PDGF)的表达水平及其意义。方法选取2016年1月至2016年9月诊治支气管哮喘患者97例作为研究对象,根据诱导痰细胞分为中性粒细胞表型组27例和嗜酸性粒细胞表型组70例。对比两组诱导痰及血清中VEGF、PDGF水平。结果嗜酸性粒细胞表型组的血清嗜酸性粒细胞(EOS)水平高于中性粒细胞表型组(P<0.05);中性粒细胞表型组和嗜酸性粒细胞表型组患者的血清、诱导痰血小板衍生生长因子AA(PDGF-AA)、血小板衍生生长因子BB(PDGF-BB)水平比较差异无统计学意义(P>0.05);嗜酸性粒细胞表型组血清、诱导痰VEGF水平高于中性粒细胞表型组(P<0.05);嗜酸性粒细胞表型支气管哮喘患者的血清EOS与血清、诱导痰VEGF水平呈显著正相关关系(P<0.05),与血清、诱导痰PDGF-AA、PDGF-BB的无显著相关性(P>0.05)。结论与中性粒细胞表型支气管哮喘患者相比,嗜酸性粒细胞表型支气管哮喘患者的血清、诱导痰VEGF水平显著升高,并且与患者血清EOS水平有显著的相关性。
Objective To investigate the expression of vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) in sera of patients with different phenotypes of bronchial asthma and its significance. Methods Ninety-seven patients with bronchial asthma were selected from January 2016 to September 2016. According to induced sputum cells, 27 cases were divided into neutrophil phenotype group and 70 cases eosinophil phenotype group. The levels of VEGF and PDGF in induced sputum and serum were compared between the two groups. Results The level of serum eosinophil (EOS) in eosinophilic phenotype group was higher than that in neutrophil phenotype group (P <0.05). The levels of serum eosinophil (EOS) in neutrophil phenotype group and neutrophil phenotype group Serum levels of induced platelet-derived growth factor AA (PDGF-AA) and platelet derived growth factor BB (PDGF-BB) had no significant difference (P> 0.05); eosinophil phenotype serum induced sputum VEGF (P <0.05). Eosinophil phenotype bronchial asthma serum EOS and serum induced sputum VEGF levels were significantly positive correlation (P <0.05), with the serum, induced There was no significant correlation between sputum PDGF-AA and PDGF-BB (P> 0.05). Conclusion Compared with neutrophil phenotype patients with bronchial asthma, eosinophilic bronchial asthma patients with serum and induced sputum VEGF levels were significantly increased, and with serum EOS levels were significantly correlated.