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目的研究慢性肾脏病(CKD)患者血脂、脂蛋白和载脂蛋白的变化特点。方法选取340例的CKD患者,根据改良的MDRD方程计算肾小球滤过率估值(e GFR),按分期将患者分4组,另选取257名健康体检者作为对照组,检测肾功能和血脂相关指标,并进行统计分析。结果与对照组比较,CKD患者Scr、BUN、UA、Cys-C、TG、TC、LDL-C和Apo B水平明显升高,而CO2-CP却降低,差异均有统计学意义(P<0.01)。随着CKD分期的进展,TG、TC、LDL-C和Apo B水平却呈下降趋势。e GFR与Scr、BUN、Cys-C、UA、TG、TC、LDL-C和Apo B呈负相关,与CO2-CP呈正相关。Scr、BUN、UA、Cys-C和Apo B是影响CKD患者e GFR水平的危险因素。结论 CKD患者血脂异常表现为TG、TC、LDL-C和Apo B升高,有必要加强对CKD患者高血脂的监测和治疗。
Objective To study the changes of blood lipids, lipoproteins and apolipoproteins in patients with chronic kidney disease (CKD). Methods A total of 340 CKD patients were selected. GFR was calculated according to the modified MDRD equation. The patients were divided into 4 groups according to the modified MDRD equation, and 257 healthy subjects were selected as the control group. The renal function and Lipid-related indicators, and statistical analysis. Results Compared with the control group, the levels of Scr, BUN, UA, Cys-C, TG, TC, LDL-C and Apo B were significantly increased in CKD patients and the levels of CO 2 -CP were significantly decreased ). With the progress of CKD staging, the levels of TG, TC, LDL-C and Apo B tended to decline. e GFR was negatively correlated with Scr, BUN, Cys-C, UA, TG, TC, LDL-C and Apo B, and positively correlated with CO2-CP. Scr, BUN, UA, Cys-C and Apo B are risk factors for e GFR in CKD patients. Conclusion The abnormalities of serum lipids in CKD patients are elevated TG, TC, LDL-C and Apo B, so it is necessary to strengthen the monitoring and treatment of hyperlipidemia in CKD patients.