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目的客观评价重组人干扰素α2b阴道泡腾片治疗宫颈柱状上皮异位的临床有效性及安全性。方法选取2014年7月-2015年11月治疗的360例宫颈柱状上皮异位患者为研究对象,随机分为试验组240例和对照组120例。试验组患者给予重组人干扰素α2b阴道泡腾片治疗,对照组患者给予重组人干扰素α2a栓治疗,比较两组患者临床疗效、治疗前后宫颈柱状上皮异位面情况、用药后病毒转阴率及安全性。结果试验组总有效率为80.52%,对照组为77.68%,试验组优于对照组,但两组差异无统计学意义(P>0.05)。治疗前、后两组患者宫颈柱状上皮异位面上下径、左右径大小差异无统计学意义(P>0.05);两组患者治疗后与治疗前比较差异均有统计学意义(P<0.01),糜烂面均明显缩小。用药后HPV6,11病毒、HPV6,18病毒、HSV病毒和HCMV病毒的转阴率,试验组分别为65.28%、66.67%、76.00%和65.38%,对照组分别为54.55%、64.10%、65.38%和58.82%,两组比较差异均无统计学意义(P>0.05)。两组均未见不良反应发生。结论重组人干扰素α2b阴道泡腾片是一种安全有效的治疗宫颈柱状上皮异位药物,值得临床推广使用。
Objective To objectively evaluate the clinical efficacy and safety of recombinant human interferon α2b vaginal effervescent tablet in the treatment of cervical columnar epithelial ectopic. Methods A total of 360 patients with cervical columnar epithelial ectopic patients who were treated from July 2014 to November 2015 were selected and randomly divided into two groups: trial group (240 cases) and control group (120 cases). Patients in the experimental group were treated with recombinant human interferon α2b vaginal effervescent tablets, and patients in the control group were treated with recombinant human interferon α2a suppositories. The clinical efficacy, cervical columnar epithelial ectopic surface before and after treatment, And safety. Results The total effective rate was 80.52% in the experimental group and 77.68% in the control group. The experimental group was better than the control group, but there was no significant difference between the two groups (P> 0.05). Before and after treatment, there was no significant difference in the size of left and right diameter of cervical columnar epithelium (P> 0.05). There was significant difference between the two groups before and after treatment (P <0.01) , Erosion surface were significantly reduced. The negative rates of HPV6,11, HPV6,18, HSV and HCMV were 65.28%, 66.67%, 76.00% and 65.38% in the test group and 54.55%, 64.10% and 65.38% in the control group, And 58.82% respectively. There was no significant difference between the two groups (P> 0.05). No adverse reactions occurred in both groups. Conclusion Recombinant human interferon α2b vaginal effervescent tablets is a safe and effective treatment of cervical columnar epithelial ectopic drugs, it is worth to promote the use of the clinic.