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非肽类ＨＩＶ－１蛋白酶抑制剂ＰＮＵ－９６９８８和ＰＮＵ－１０３０１７是尚在研制中可口服治疗ＡＩＤＳ的代表性药物，它们能够与血清蛋白发生强烈结合。本研究评价了这两种蛋白酶抑制剂与人血清白蛋白的结合对其在离体人外周血单核细胞（ＰＢＭＣ）中平衡分布的影响，同时
Non-peptide HIV-1 protease inhibitors PNU-96988 and PNU-103017 are representative drugs that are still under development for the treatment of AIDS and are capable of strongly binding to serum proteins. This study evaluated the effect of the binding of these two protease inhibitors to human serum albumin on their equilibrium distribution in isolated human peripheral blood mononuclear cells (PBMCs)