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血管存在于肿瘤组织内部时,肿瘤组织靠近血管的边界部分会受到血管冷却效应的较大影响,这种影响会导致肿瘤治疗不彻底。针对此种情况,以凹球面换能器作为仿真热源,通过瑞利积分求得声强分布,并利用有限差分法对生物热传导方程进行求解,结合加热时间和温度的定量关系,计算出热剂量分布情况来判定组织的热损伤程度,研究血流对加热的影响。仿真结果表明:由于血管的存在,损伤区域被分成两部分,焦域内热剂量减小;血管尺寸、血流速度或血液灌注率增大,有效热剂量范围明显减小;血管越靠近焦域中心,其影响越大。
When blood vessels exist inside the tumor tissue, the boundary of the tumor tissue near the blood vessel is greatly affected by the cooling effect of the blood vessel, which may result in incomplete tumor treatment. In this case, the concave spherical transducer is used as the simulation heat source, the sound intensity distribution is obtained by Rayleigh integral, and the biological heat conduction equation is solved by the finite difference method. Combined with the quantitative relationship between heating time and temperature, the heat dose Distribution to determine the extent of tissue damage, study the impact of blood flow on heating. The simulation results show that due to the presence of blood vessels, the damaged area is divided into two parts, and the thermal dose in the focal area decreases; the size of the blood vessel, blood flow rate or blood perfusion rate increases, the effective thermal dose range is significantly reduced; the closer the vessel is to the focal center , The greater its impact.