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A组溶血性链球菌是一种常见的致病性化脓链球菌,近年来由于链球菌导致的疾病发生及侵袭性感染不断增多,其耐药性不断增强,该病原体逐渐引起研究者们的重视。链球菌的致病性和其所携带的致病因子密切相关,目前已发现多种链球菌致病因子,包括表膜蛋白、链球菌溶血素,透明质酸酶、致热外毒素、链激酶及DNA酶等。其中,链球菌发热性外毒素Spe B是目前研究比较多的一种致病因子,其在穿越宿主免疫屏障、破坏血凝系统、引起炎症反应、逃避免疫系统并引起免疫交叉反应中起重要作用,本文就Spe B的最新研究进展进行综述。
Group A hemolytic streptococcus is a common pathogenic Streptococcus pyogenes, in recent years due to Streptococcus-induced diseases and invasive infections continue to increase, its resistance continues to increase, the pathogens gradually attracted the attention of researchers . The pathogenicity of streptococci is closely related to the pathogenic factors they carry. So far, many streptococcal pathogenic factors have been found, including epidermal proteins, streptolysin, hyaluronidase, pyrogen exotoxin, streptokinase And DNA enzymes. Among them, Streptococcus fever exotoxin Spe B is a causative factor currently studied, which plays an important role in crossing the host immune barrier, destroying the hemagglutination system, causing inflammatory reactions, evaporating the immune system and causing immune cross-reactions This article reviews Spe B’s latest research.