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幽门螺杆菌(Hp)感染是消化性溃疡和慢性胃炎的重要发病因素,Hp在胃内的分布不均匀。为使Hp感染的区域在内镜下变为可视,作者以溴甲酚紫—尿素喷洒成色内镜检测有无Hp感染及其所在部位。作者共检测各种胃十二指肠疾病256例,男185例,女71例,平均年龄40.6岁。做法是在内镜下经活检孔道将Hp识别液5～10ml喷洒在球部、胃窦幽门区,有糜烂、充血、溃疡、疣状凹陷等病变处,1～2分钟后上述各部如呈紫色即示Hp存在。结果本组阳性者128例,阳性率50.0%。在阳性着色区做粘膜活检,做涂片和石蜡切片用作者研制的乙醇中性红染色,结果100%检出Hp。未着色者128例,也作粘膜活检,检查有无Hp,结果仅有2例浅表性胃炎有Hp感染,染色法的假阴性率1.56%。作者认为,本技术准确、无创、简便、实用,可作为Hp诊断及治疗清除的可靠指标。
Helicobacter pylori (Hp) infection is an important pathogenesis of peptic ulcer and chronic gastritis, Hp distribution in the stomach uneven. In order to visualize the area of Hp infection under endoscopy, the authors used bromocresol purple-urea spray-dye endoscopy to detect the presence of Hp infection and its location. The authors detected a variety of gastroduodenal diseases in 256 cases, 185 males and 71 females, with an average age of 40.6 years. Practice is endoscopic biopsy will Hp recognition fluid spray 5 ~ 10ml ball, pyloric area of the antrum, there erosion, congestion, ulcers, verrucous depression and other lesions at 1 to 2 minutes after the above ministries were purple That shows Hp exists. Results 128 patients were positive in this group, the positive rate was 50.0%. In the positive staining area mucosal biopsy done smear and paraffin sections developed by the author neutral red staining of ethanol, the results of 100% detection of Hp. 128 cases of non-coloring, but also for mucosal biopsy, check for the presence or absence of Hp, the results of only 2 cases of superficial gastritis with Hp infection, false-negative staining rate of 1.56%. The authors believe that the technology is accurate, noninvasive, simple and practical, can be used as a reliable indicator of Hp diagnosis and treatment of clear.