论文部分内容阅读
目的探讨血清透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(IV-C)、层粘连蛋白(LN)在肝纤维化中的诊断价值。方法应用放射免疫分析法(RIA)联合检测148例慢性肝炎患者血清HA、PCⅢ、IV-C和LN含量并进行分析。结果血清HA、PCⅢ、IV-C和LN水平在慢性肝炎中度、高度及肝硬化患者均明显高于对照组(P<0.05),且随着肝脏炎症和纤维化程度的加重而升高。结论联合检测HA、PCⅢ、IV-C和LN含量可较好的反映肝纤维化及肝实质损害的程度,并能为临床诊断及治疗提供依据。
Objective To investigate the diagnostic value of serum hyaluronic acid (HA), type Ⅲ procollagen (PC Ⅲ), type Ⅳ collagen (IV-C) and laminin (LN) in liver fibrosis. Methods The contents of HA, PCⅢ, IV-C and LN in 148 patients with chronic hepatitis were detected by radioimmunoassay (RIA) and analyzed. Results Serum levels of HA, PCⅢ, IV-C and LN were significantly higher in chronic hepatitis patients with moderate, severe and cirrhosis than those in control group (P <0.05), and increased with the severity of liver inflammation and fibrosis. Conclusion The combined detection of HA, PCⅢ, IV-C and LN levels can better reflect the degree of hepatic fibrosis and hepatic parenchymal damage, and provide a basis for clinical diagnosis and treatment.