论文部分内容阅读
目的探讨不稳定型心绞痛(UA)患者血清血管紧张素Ⅱ(AngⅡ)、高敏C-反应蛋白(hs-CRP)和基质金属蛋白酶-9(MMP-9)水平的变化及相互间关系。方法选取符合纳入标准的50例UA患者、50例稳定型心绞痛(SA)患者和50例对照者。对150例入选患者测定血清AngⅡ、hs-CRP和MMP-9水平。比较各组间血清AngⅡ、hs-CRP和MMP-9水平并分析其相关性。结果 UA组血清AngⅡ、hs-CRP和MMP-9水平均显著高于对照组,差异有统计学意义(P<0.001)。UA组血清AngⅡ、hs-CRP和MMP-9水平高于SA组,差异有统计学意义(P<0.05)。SA组血清AngⅡ、hs-CRP和MMP-9水平与对照组比较差异无统计学意义(P>0.05)。UA组AngⅡ与hs-CRP相关性分析呈正相关:r=0.309,P=0.000。AngⅡ与MMP-9相关性分析呈正相关:r=0.510,P=0.000。MMP-9与hs-CRP相关性分析呈正相关:r=0.615,P=0.000。结论血清hs-CRP、MMP-9和AngⅡ水平的增高与UA有关,可作为评价冠状动脉粥样硬化斑块稳定性一个参考指标。UA组血清AngⅡ、hs-CRP和MMP-9三者之间存在一定的相关性。
Objective To investigate the changes of serum angiotensin Ⅱ (Ang Ⅱ), high sensitive C-reactive protein (hs-CRP) and matrix metalloproteinase-9 (MMP-9) in patients with unstable angina pectoris (UA) Methods Fifty UA patients, 50 patients with stable angina pectoris (SA) and 50 controls were enrolled in the study. Serum levels of AngⅡ, hs-CRP and MMP-9 were measured in 150 selected patients. The levels of serum AngⅡ, hs-CRP and MMP-9 in each group were compared and analyzed. Results The levels of serum AngⅡ, hs-CRP and MMP-9 in UA group were significantly higher than those in control group (P <0.001). The levels of serum AngⅡ, hs-CRP and MMP-9 in UA group were significantly higher than those in SA group (P <0.05). The levels of serum AngⅡ, hs-CRP and MMP-9 in SA group were not significantly different from those in control group (P> 0.05). There was a positive correlation between Ang II and hs-CRP in UA group (r = 0.309, P = 0.000). Correlation analysis between AngⅡ and MMP-9 showed a positive correlation: r = 0.510, P = 0.000. Correlation analysis between MMP-9 and hs-CRP showed a positive correlation: r = 0.615, P = 0.000. Conclusions The increase of hs-CRP, MMP-9 and AngⅡ in serum is related to UA, which can be used as a reference index to evaluate the stability of atherosclerotic plaque. UA group of serum Ang Ⅱ, hs-CRP and MMP-9 there is a certain correlation between the three.