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目的 分析糖尿病患者F-ERG振幅、峰潜时、OPS总和振幅及其与病程的相关性,以加深对DR的认识。方法采用美国UATA-2000型视觉电生理仪对53例糖尿病患者进行F-ERG检查,主要分析其a、b波峰潜时、振幅,OPS总和振幅。结果 随着DR病情的加重,ERG及OPS无波的情况所占比例增大。a波峰潜时BDR组和正常组比较有极显著性差异(ρ<0.01),BDR组和DN无DR组比较有显著性差异(ρ<0.05);a波振幅正常对照组与其它各组比较均有极显著性差异(ρ<0.01)。b波振幅正常对照组与BDR、PDR间以及DM无DR组与BDR、PDR组间均有极显著性差异(ρ<0.01)。OPS总和振幅除了BDR与PDR间外其它各组比较均有极显著性差异(ρ<0.01)。各指标与病程之间均无明显相关关系(经检验所有ρ>0.05)。结论 OPS、ERG之a、b波振幅,尤其是b波振幅,可以作为早期诊断DR患者以及估计预後的敏感指标,良好的血糖控制,可以延缓DM的病情发展。
OBJECTIVE: To analyze the amplitude of F-ERG, the peak latency, the amplitude of OPS, and its relationship with the course of disease in diabetic patients to deepen the understanding of DR. Methods F-ERG was performed in 53 patients with diabetes mellitus by using American UATA-2000 visual electrophysiology instrument. The main a, b peak latency, amplitude and amplitude of OPS were analyzed. Results With the exacerbation of DR, the proportion of cases without ERG and OPS increased. (P <0.01). There was significant difference between BDR group and DN without DR group (ρ <0.05). The amplitude of a-wave amplitude in normal control group was significantly higher than that in other groups There was a significant difference (ρ <0.01). There was a significant difference in the amplitude of b wave between the control group and the BDR and PDR as well as between the DM without DR group and the BDR and PDR groups (ρ <0.01). The amplitudes of OPS except the BDR and PDR were significantly different (p <0.01). There was no significant correlation between each index and the course of disease (all tested ρ> 0.05). Conclusions The amplitude of a and b wave, especially the amplitude of b wave in OPS and ERG can be used as a sensitive index for early diagnosis of DR patients and prognosis. Good glycemic control can delay the progression of DM.