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目的探讨细胞周期素D1(cyclin D1)和生存素(survivin)的表达与食管鳞癌临床病理因素和预后的相关性。方法应用免疫组织化学方法检测80例食管鳞癌中周期素D1和生存素的表达。结果细胞周期素D1和生存素阳性率分别为61.25%和65.00%。细胞周期素D1和生存素的表达均与淋巴结转移、TNM分期呈正相关(P<0.05)。生存素还与癌组织学分级有关(P<0.05),且与细胞周期素D1表达亦呈正相关(P<0.01)。多因素(Cox比例风险模型)生存分析显示食管鳞癌细胞周期素D1和生存素均是独立的预后因素(P<0.05)。结论细胞周期素D1和生存素均在食管鳞癌中高表达。均是影响预后的主要因素。
Objective To investigate the relationship between the expression of cyclin D1 and survivin and the clinicopathological parameters and prognosis of esophageal squamous cell carcinoma. Methods Immunohistochemistry was used to detect the expression of cyclin D1 and survivin in 80 cases of esophageal squamous cell carcinoma. Results The positive rates of cyclin D1 and survivin were 61.25% and 65.00% respectively. The expressions of cyclin D1 and survivin were positively correlated with lymph node metastasis and TNM stage (P <0.05). Survivin also correlated with histological grade (P <0.05), and positively correlated with cyclin D1 expression (P <0.01). Multivariate (Cox proportional hazard model) survival analysis showed that cyclin D1 and survivin were both independent prognostic factors for esophageal squamous cell carcinoma (P <0.05). Conclusion Cyclin D1 and survivin are highly expressed in esophageal squamous cell carcinoma. Are the main factors that affect the prognosis.