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目的:观察淫羊藿苷对酒精损伤小鼠睾丸生精细胞凋亡的影响,探讨淫羊藿苷对酒精损伤小鼠睾丸的保护作用。方法:健康成年雄性小鼠,随机分为对照组(蒸馏水)、模型组(酒精组)和给药组(酒精+淫羊藿苷组),连续灌胃5周,制备睾丸组织标本,HE染色观察生精小管结构,Tunel法观察睾丸生精细胞凋亡。结果:对照组睾丸生精细胞凋亡指数为(2.09±0.15),模型组凋亡指数为(10.92±1.02),给药组凋亡指数为(5.50±0.51),与对照组比较,模型组细胞凋亡明显增多,生精细胞层数减少,生精小管结构混乱;与模型组比较,给药组细胞凋亡减少,生精小管结构明显改善。结论:淫羊藿苷对酒精损伤小鼠睾丸具有保护作用。
Objective: To observe the effect of icariin on the apoptosis of spermatogenic cells in testes of alcohol-lesioned mice and to explore the protective effect of icariin on testes in alcohol-lesioned mice. Methods: Healthy adult male mice were randomly divided into control group (distilled water), model group (alcohol group) and administration group (alcohol + icariin group) for 5 weeks. The testicular tissue samples were prepared and HE staining The structure of seminiferous tubules was observed. The apoptosis of spermatogenic cells in testis was observed by Tunel method. Results: The apoptotic index of testicular spermatogenic cells in control group was (2.09 ± 0.15), the apoptotic index in model group was (10.92 ± 1.02), and the apoptotic index in treated group was (5.50 ± 0.51). Compared with control group, Compared with model group, apoptosis of the treated group decreased and the structure of seminiferous tubules improved obviously. Conclusion: Icariin has a protective effect on testis in alcohol-injured mice.