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我们将小鼠置于人工风寒环境中刺激10h后,观察到其网状内皮系统(RES)廓清功能及φ腹腔巨噬细胞φ(PM噬)释放H_2O_2量均受到明显抑制,动力学观察结果表明,免疫抑制高峰发生在风寒刺激后第3天,刺激后第5天、第7天逐渐恢复正常,表现出一过性免疫抑制。免疫抑制的原因可能是风寒刺激过程中应激激素大量分泌所致。提示中医六气病因学说中的风寒二气,其致病的作用机理可能与抑制机体非特异性细胞免疫功能有关,该结论可与《内经》的“邪之所凑,其气必虚”发病理论相映证。
After 10 hours of stimulation in the artificial cold environment, we observed that the reticuloendothelial system (RES) clearance function and φ peritoneal macrophage φ (PM ) release H 2 O 2 amount were all significantly inhibited. Kinetic observations showed that The peak of immunosuppression occurred on the 3rd day after the cold stimulation, and gradually returned to normal on the 5th and 7th days after the stimulation, showing transient immunosuppression. The reason for immunosuppression may be due to the massive secretion of stress hormones during the cold stimulation. It is suggested that the pathogenic mechanism of Chinese medicine in the Six qi etiology may be related to the suppression of the body’s non-specific cellular immune function. This conclusion may be related to the “necessity of evil” in Neijing. Symptoms of disease theory.