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采用免疫组织化学Ｓ－Ｐ法检测５２例手术切除乳腺癌组织ｃ－ｅｒｂＢ－２蛋白和ＨＳＶ－１、ＨＳＶ－２表达情况。结果发现癌组织中ｃ－ｅｒｂＢ－２阳性３４例（６５．４％）；ＨＳＶ－１阳性３８例（７３．１％）；ＨＳＶ－２阳性１５例（２８．８％）。癌旁组织３２例，阳性分别为３例（９．４％）；１２例（３７．５％）；２例（６．３％）。乳腺癌中ｃ－ｅｒｂＢ－２阳性率明显高于癌旁组织。乳腺癌及癌旁的ＨＳＶ－１阳性率明显高于ＨＳＶ－２，乳腺癌ｃ－ｅｒｂＢ－２阳性组中ＨＳＶ－１和ＨＳＶ－２的表达有显著差异，而在阴性组二者无差异，提示乳腺癌的发生可能和ＨＳＶ－１感染密切相关，ｃ－ｅｒｂＢ－２表达也可能和ＨＳＶ－１感染有关。
The expression of c-erbB-2 protein and HSV-1 and HSV-2 in 52 cases of breast cancer were detected by immunohistochemical S-P method. The results showed that c-erbB-2 was positive in 34 cases (65.4%); HSV-1 was positive in 38 cases (73.1%); HSV-2 was positive in 15 cases (28.8%). Thirty-two paracancerous tissues were positive, including 3 cases (9.4%), 12 cases (37.5%), and 2 cases (6.3%). The positive rate of c-erbB-2 in breast cancer was significantly higher than that in adjacent tissues. The positive rate of HSV-1 in breast cancer and adjacent cancer was significantly higher than that in HSV-2. There was a significant difference in the expression of HSV-1 and HSV-2 in the positive breast cancer c-erbB-2 group, but there was no difference in the negative group. It suggests that the occurrence of breast cancer may be closely related to HSV-1 infection, and the expression of c-erbB-2 may also be related to HSV-1 infection.