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目的观察“中药三步周期疗法”对Ⅳ期大肠癌患者XELOX方案化疗后生存质量的影响。方法 80例患者,随机分为2组,对照组39例,治疗组41例。对照组:单纯改良XELOX方案化疗(L-OHP 130mg/m2,d1;CAP 1000mg/m2,bid,d1-14;q4w×4周期);治疗组:“中药三步周期疗法”联合改良XELOX方案化疗,共服中药汤剂4周期。观察临床主要症状、生命质量(EORTC QLQ-C30)、Karnofsky评分、细胞免疫功能等指标。结果在临床主要症状改善(总有效率为75.61%对17.95%)、Karnofsky评分提高(总有效率为75.61%对17.95%)、细胞免疫功能改善(总有效率为70.73%对15.38%)指标上,治疗组明显优于对照组(P<0.05)。根据EORTC QLQ-C30测定,在躯体功能、角色功能、情绪功能、认知功能、总体健康状况及疲倦、恶心呕吐、失眠、食欲丧失、腹泻等方面,治疗组的改善优于对照组(P<0.05)。结论 “中药三步周期疗法”可明显改善Ⅳ期大肠癌患者化疗后的生存质量。
Objective To observe the effects of traditional Chinese medicine three-cycle therapy on the quality of life of patients with stage Ⅳ colorectal cancer after XELOX chemotherapy. Methods Eighty patients were randomly divided into two groups: control group (39 cases) and treatment group (41 cases). The patients in the control group were treated with modified XELOX regimen alone (L-OHP 130 mg / m2, d1; CAP 1000 mg / m2, bid, d1-14; q4w × 4 cycles) Program chemotherapy, serving a total of Chinese medicine decoction 4 cycles. Main clinical symptoms, quality of life (EORTC QLQ-C30), Karnofsky score and cellular immune function were observed. Results The improvement of clinical symptoms (total effective rate was 75.61% vs 17.95%), Karnofsky score increased (total effective rate was 75.61% vs 17.95%), cellular immune function improved (total effective rate was 70.73% vs 15.38%) , The treatment group was significantly better than the control group (P <0.05). According to the EORTC QLQ-C30 test, the improvement of the treatment group was better than that of the control group in physical function, role function, emotional function, cognitive function, general health and tiredness, nausea and vomiting, insomnia, loss of appetite and diarrhea (P < 0.05). Conclusion “Three-cycle therapy of traditional Chinese medicine” can significantly improve the quality of life of patients with stage Ⅳ colorectal cancer after chemotherapy.