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1例13岁男性急性淋巴细胞白血病异基因移植术后患儿因肺部感染静脉滴注阿奇霉素20.8 mg/kg(患儿体重24 kg)。首次静脉滴注阿奇霉素即将结束时,患儿出现心悸,心率225次/min,血压75/45 mmHg(1mmHg=0.133 kPa),脉搏血氧饱和度0.98;心电图提示室上性心动过速,QRS波变窄;床边心脏超声检查示心包少量积液,左心室后壁运动稍减弱,射血分数0.58。立即停用阿奇霉素,交替压迫患儿颈动脉窦和眼球,约10 min后患儿心率降至120次/min,心率为窦性,血压92/62 mmHg。2 d后心电图正常,心率87次/min。
One case of 13-year-old male with acute lymphoblastic leukemia after allogeneic transplantation was infused with azithromycin 20.8 mg / kg (with a body weight of 24 kg) for pulmonary infection. The first intravenous infusion of azithromycin is about to end, the children had palpitations, heart rate 225 beats / min, blood pressure 75/45 mmHg (1mmHg = 0.133kPa), pulse oximetry 0.98; ECG prompted supraventricular tachycardia, QRS wave Narrowing; bedside cardiac ultrasound showed a small amount of effusion fluid, left ventricular posterior wall motion slightly weakened, ejection fraction 0.58. Immediately stop azithromycin, alternating with children with carotid sinus and eye pressure, heart rate after about 10 min to 120 beats / min, heart rate sinus, blood pressure 92/62 mmHg. 2 d after normal ECG, heart rate 87 beats / min.