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探讨血透患者血浆内皮素1(ET1)、血管紧张素Ⅱ(ATⅡ)浓度改变及其与心肌肥厚的关系。方法采用放射免疫的方法。结果(1)血透4小时后ET1较血透前降低,透后72小时再次升高。(2)血透4小时后ATⅡ较血透前升高,透后72小时仍高于透前水平。(3)维持血透3个月后左室重量(LVM)、左室重量指数(LVMI)较3个月前明显升高。(4)血透患者BUN、Scr、ET1、ATⅡ均与LVMI呈正相关。结论血透患者LVH可能与血浆ET1、ATⅡ升高有关,维持血透不能持久降低其浓度。
To investigate the changes of plasma endothelin-1 (ET-1) and angiotensin Ⅱ (ATⅡ) concentrations in patients with hemodialysis and its relationship with cardiac hypertrophy. Methods Using radioimmunoassay method. Results (1) 4 hours after hemodialysis than ET 1 hemodialysis before hemodialysis, increased again 72 hours later. (2) 4 hours after hemodialysis, AT Ⅱ hemodialysis than before, through 72 hours is still higher than before the level of. (3) Maintaining left ventricular mass (LVM) and left ventricular mass index (LVMI) after 3 months of hemodialysis were significantly higher than those 3 months earlier. (4) BUN, Scr, ET-1 and AT-II in hemodialysis patients were positively correlated with LVMI. Conclusion Hemodialysis patients with LVH may be related to plasma ET 1, AT Ⅱ elevated, maintaining hemodialysis can not be sustained to reduce its concentration.