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探讨血透患者血浆内皮素１（ＥＴ１）、血管紧张素Ⅱ（ＡＴⅡ）浓度改变及其与心肌肥厚的关系。方法采用放射免疫的方法。结果（１）血透４小时后ＥＴ１较血透前降低，透后７２小时再次升高。（２）血透４小时后ＡＴⅡ较血透前升高，透后７２小时仍高于透前水平。（３）维持血透３个月后左室重量（ＬＶＭ）、左室重量指数（ＬＶＭＩ）较３个月前明显升高。（４）血透患者ＢＵＮ、Ｓｃｒ、ＥＴ１、ＡＴⅡ均与ＬＶＭＩ呈正相关。结论血透患者ＬＶＨ可能与血浆ＥＴ１、ＡＴⅡ升高有关，维持血透不能持久降低其浓度。
To investigate the changes of plasma endothelin-1 (ET-1) and angiotensin Ⅱ (ATⅡ) concentrations in patients with hemodialysis and its relationship with cardiac hypertrophy. Methods Using radioimmunoassay method. Results (1) 4 hours after hemodialysis than ET 1 hemodialysis before hemodialysis, increased again 72 hours later. (2) 4 hours after hemodialysis, AT Ⅱ hemodialysis than before, through 72 hours is still higher than before the level of. (3) Maintaining left ventricular mass (LVM) and left ventricular mass index (LVMI) after 3 months of hemodialysis were significantly higher than those 3 months earlier. (4) BUN, Scr, ET-1 and AT-II in hemodialysis patients were positively correlated with LVMI. Conclusion Hemodialysis patients with LVH may be related to plasma ET 1, AT Ⅱ elevated, maintaining hemodialysis can not be sustained to reduce its concentration.