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目的探讨子宫内膜异位症(endometriosis,EM)与特定类型卵巢癌风险的相关性。方法单纯EM患者123例为单纯组,卵巢癌未合并EM患者69例为未合并组,卵巢癌合并EM患者9例为合并组。检测各组血清人附睾蛋白4(human epididymis protein 4,HE4)、糖链抗原125(carbohydrate antigen 125,CA125)水平,计算ROMA风险指数,并对卵巢癌患者病理分期、类型进行分析。结果合并组CA125[(389.91±13.79)u/mL]、HE4[(318.64±30.17)pmol/L]、ROMA指数[(90.48±7.13)%]高于未合并组[(367.94±12.94)u/mL、(220.67±28.47)pmol/L、(57.81±6.55)%]和单纯组[(30.72±9.07)u/mL、(68.91±15.49)pmol/L、(23.07±2.01)%],未合并组CA125、HE4、ROMA指数高于单纯组,组间比较差异均有统计学意义(P<0.05);未合并组患者病理分期多为Ⅰ期,以浆液性腺癌为主,合并组多为Ⅲ期,病理类型主要为透明细胞癌和子宫内膜样腺癌,2组病理分期、类型比较差异均有统计学意义(P<0.05)。结论EM有发生卵巢癌的风险,且与透明细胞癌和子宫内膜样腺癌发生有一定相关性,多数患者病理分化程度较低。
Objective To investigate the relationship between endometriosis (EM) and the risk of ovarian cancer of a specific type. Methods 123 patients with simple EM were simple group, 69 patients with ovarian cancer without EM were non-combined group, and 9 patients with ovarian cancer complicated with EM were combined group. The serum levels of human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125) in each group were detected and the ROMA risk index was calculated. The pathological stage and type of ovarian cancer patients were also analyzed. Results Compared with the non-combined group [(367.94 ± 12.94) u / mL], ROMA index [(90.48 ± 7.13)%] mL, (220.67 ± 28.47) pmol / L, (57.81 ± 6.55)%] and the pure group (30.72 ± 9.07 u / mL, 68.91 ± 15.49 pmol / L, 23.07 ± 2.01% Group CA125, HE4, ROMA index higher than the simple group, the difference between the groups were statistically significant (P <0.05); non-combined group of patients with pathological stage mostly Ⅰ, serous adenocarcinoma, the combined group mostly Ⅲ The main pathological types were clear cell carcinoma and endometrioid adenocarcinoma. There were significant differences in the two groups (P <0.05). Conclusion EM has the risk of ovarian cancer, and has some correlation with clear cell carcinoma and endometrial adenocarcinoma. Most patients have a lower degree of pathological differentiation.