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统计分析浙江省海宁市1978年大肠癌普查资料及浙江医科大学附属第一医院1979年6月至1992年6月1712例大肠癌病案；登记了29个家系的37例家族性腺癌性息肉病（FAP）病人，完成其中14个家系调查，并对部分家系进行了眼底检查，统计FAP患病率为1．51／10万，FAP病变占大肠癌的0．94％。肠镜筛检57个高危亲属，发现18例新病人，病人中位年龄19岁，癌变率5．65％，显著低于求诊病人中位年龄31岁，癌变率64％（P均＜0．05）；眼底检查8例病人与4个正常亲属，病人均有先天性视网膜色素上皮增生（CHRPE）病变，而正常亲属无此病变。结果表明FAP并非很少见病，是大肠癌病因之一，理应重视；开展病人登记和家系调查对其早期诊断与癌变防治具有重要意义，眼底检查CHRPE病变可作筛检FAP新方法，此方法可靠、无创，值得推广。本文还探讨了FAP的发病情况和开展病人登记与家系调查的意义和方法。
Statistical analysis of 1978 colorectal cancer screening data of Haining City, Zhejiang Province, and the 1712 cases of colorectal cancer from June 1979 to June 1992 in the First Affiliated Hospital of Zhejiang Medical University; 37 cases of familial adenocarcinoma of polyposis were registered in 29 families ( FAP) patients completed 14 family surveys and fundus examinations were performed on some families. The prevalence of FAP was 1.51 per 100,000 and FAP lesions accounted for 0.94% of colorectal cancer. Colonoscopy screened 57 high-risk relatives and found 18 new patients. The median age of the patients was 19 years and the cancer rate was 5.65%, which was significantly lower than the median age of patients seeking treatment at 31 years and the canceration rate was 64% (P <0 .05); fundus examination of 8 patients and 4 normal relatives, patients with congenital retinal pigment epithelial hyperplasia (CHRPE) lesions, and normal relatives without this lesion. The results show that FAP is not a rare disease, is one of the causes of colorectal cancer, should pay attention to; carry out patient registration and family survey is important for its early diagnosis and prevention of cancer, fundus examination CHRPE lesions can be used as a new method of screening FAP, this method Reliable, non-invasive, worth promoting. This article also discusses the incidence of FAP and the significance and methods of conducting patient registration and family surveys.