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利用表面引发原子转移自由基聚合(SI-ATRP)技术将聚(甲基丙烯酸寡聚乙二醇酯)和聚(甲基丙烯酸缩水甘油酯)的双嵌段共聚物刷(POEGMA-b-PGMA)接枝在材料表面,并通过PGMA中丰富的环氧基团开环固定可特异性黏附内皮细胞的多肽GREDVY.静态水接触角、接枝层厚度、X射线光电子能谱(XPS)以及原子力显微镜(AFM)的测试结果证明了各步接枝反应的成功性.细胞培养研究表明这种连接有GREDVY的双嵌段共聚物表面能够有效的促进血管内皮细胞的黏附,同时排斥成纤维细胞的黏附,从而实现了内皮细胞的选择性黏附.
The diblock copolymer brush (POEGMA-b-PGMA) of poly (methacrylic acid oligoethylene glycol ester) and poly (glycidyl methacrylate) was surface-initiated by atom transfer radical polymerization (SI-ATRP) ) Was grafted on the surface of the material, and GREDVY, a static water contact angle, grafted layer thickness, X-ray photoelectron spectroscopy (XPS) and atomic force The results of microscopic examination (AFM) proved the success of the grafting reaction of each step.Cell culture studies show that the surface of this GREDVY-linked diblock copolymer can effectively promote the adhesion of vascular endothelial cells while rejecting fibroblasts Adhesion, in order to achieve the selective adhesion of endothelial cells.