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目的:探讨碱性成纤维生长因子(bFGF)在磅脱移行细胞癌(BTCC)中表达的意义.方法:应用免疫组化ABC法对33例BTCC及12例正常膀胱组织中bFGF抗原进行检测.结果:bFGF在正常移行细胞呈阴性表达.在肿瘤细胞、血管内皮细胞、肌细胞中呈阳性表达,且在肿瘤细胞中的过表达率与不同病理分级、临床分期密切相关(P＜0.05),在单发与多发,初发与复发组间无显著性差异(P＞0.05).结论:bFGF在BTCC浸润转移过程中起重要作用,可为综合治疗提供新途径.“,”Aim: To evaluate the significance of basic fibrob1ast growth factor receptor (bFGF) ex-Pression in human transitional cell carcinoma of b1adder (BTCC). Methods: The expression of bFGF wasdetected by standard ABC immunohistochemical technique in 33 paraffin - embedded tissue specimens ofBTCC. Results: All normal transitional cells were negatively stained in bFGF. Neoplastic cells, musclecells and endothelial cells of vessels were positively stained. Strongly positive expression of bFGF in tumorcells correlated closely with different pathological grades and clinical stages (both P 0. 05). Conclusion: bFGF played a important role on the process of BTCC invasivenessand metastasis. This marker may become a new tafget for comprehensive treatments of BTCC.