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目的 评价抗中性粒细胞胞浆抗体 (ANCA)与肾脏疾病关联及其诊断、随访价值 ,初步探讨不典型ANCA(A ANCA)的临床意义。方法 以IIF法、ELISA法联合检测ANCA及其靶抗原。结果 2 7例ANCA阳性 :16例原发性系统性血管炎 (4例C ANCA+ /PR3 ANCA+ ,7例P ANCA+ /MPO ANCA+ ,4例P ANCA+ /抗原不明 ,1例C ANCA+ /抗原不明 ) ,2例紫癜肾 (P ANCA+ /抗原不明 ) ,3例SLE(P ANCA+ /LF ANCA+ ) ,此外A ANCA6例。结论 PR3 ANCA、MPO ANCA为原发性系统性血管炎重要诊断、分型和随访指标 ,LF ANCA与SLE肾脏损害无关联 ,A ANCA检出于自身免疫性疾病 ,较多肝、肾间质受累
Objective To evaluate the association between anti-neutrophil cytoplasmic antibody (ANCA) and renal disease and the value of its diagnosis and follow-up, and to explore the clinical significance of atypical ANCA. Methods Combined detection of ANCA and its target antigen by IIF and ELISA. RESULTS: Twenty-seven ANCA-positive patients: 16 patients with primary systemic vasculitis (4 C ANCA + / PR3 ANCA +, 7 P ANCA + / MPO ANCA +, 4 P ANCA + / antigen unknown, 1 C ANCA + / antigen unknown) 2 cases of purpura kidney (P ANCA + / antigen unknown), 3 cases of SLE (P ANCA + / LF ANCA +), in addition A ANCA6 cases. Conclusions PR3 ANCA and MPO ANCA are important diagnostic, classification and follow-up indexes of primary systemic vasculitis. LF ANCA is not associated with renal damage in SLE. A ANCA is detected in autoimmune diseases, with more liver and renal interstitium involvement