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本研究对31例慢性糜烂性胃炎粘膜活检组织及14例手术切除的胃癌组织的P21ras、P53蛋白、细胞核增殖抗原（PCNA）、癌胚抗原（CEA）的表达采用LSAB免疫组织化学标记。结果发现P21ras在慢性糜烂性胃炎粘膜上皮和胃癌肿瘤细胞中表达阳性率分别为67.7％和65.0％（P>0.05）;P53表达阳性率分别为0和21.4％（0.010.05）;CEA表达阳性率分别为29.0％和78.6％（P<0.01）。慢性糜烂性胃炎较高的P21ras表达和较高的细胞增生活性（PCNA表达）,提示其有一定的转化趋势。慢性糜烂性胃炎粘膜上皮的CEA表达可能提示其为今后发展成肠型胃癌的前驱病变。
In this study, the expression of P21ras, P53 protein, proliferating cell nuclear antigen (PCNA) and carcinoembryonic antigen (CEA) in 31 cases of chronic erosive gastritis mucosa biopsy and 14 cases of surgical resection of gastric cancer tissue were detected by LSAB immunohistochemistry. The results showed that the positive rate of P21ras in chronic erosive gastritis mucosal epithelium and gastric cancer cells was 67.7% and 65.0%, respectively (P>0.05); the positive rate of P53 expression was 0 and 21.4% (0.010.05); the positive rate of CEA expression was 29.0% and 78.6%, respectively (P<0.01). The higher expression of P21ras and higher cell proliferation activity (PCNA expression) in chronic erosive gastritis suggests that it has a certain conversion trend. The CEA expression in the mucosal epithelium of chronic erosive gastritis may suggest that it is a precursor disease that develops into intestinal type gastric cancer in the future.