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肝纤维化是慢性肝病的主要病理改变,其发生、发展与肝病的进展和预后有着密切的关系。目前临床上对肝纤维化最佳的诊断途径是靠肝穿活组织检查来确诊,但由于穿刺的局限性、创伤性和难以进行动态观察从而受到了限制。近年来在寻求肝硬化早期诊断及肝纤维化动态观察临床指标这方面的课题日益受到人们的重视。自1979年Rohde首先建立放免法测定血清PⅢP(Ⅲ型前胶原肽),并表明其对肝纤维化诊断有良好的诊断意义以来,此法已有较多报道,而血清PcⅢ(Ⅲ型前胶原)的检测报道尚少。我们通过测定各种肝病患者血清Pc Ⅲ含量以探讨血清Pc Ⅲ对肝纤维化诊断的价值。
Liver fibrosis is the main pathological change of chronic liver disease. The occurrence and development of liver fibrosis are closely related to the progress and prognosis of liver disease. Currently the best clinical diagnosis of liver fibrosis by liver biopsy to confirm the diagnosis, but because of the limitations of puncture, traumatic and difficult to observe the dynamic has been limited. In recent years, in the search for early diagnosis of cirrhosis and liver fibrosis dynamic observation of clinical indicators in this area, the subject of increasingly attention. Rohde first established in 1979 by radioimmunoassay determination of serum P Ⅲ P (procollagen Ⅲ), and shows that it has a good diagnostic value of the diagnosis of liver fibrosis, this method has been more reported, and serum Pc Ⅲ (procollagen type Ⅲ ) Detection report is still small. We determined the serum Pc Ⅲ levels in patients with various liver diseases to explore the value of serum Pc Ⅲ in the diagnosis of liver fibrosis.