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目的:观察痰热清注射液对肺腺癌化疗后并发肺部感染患者的疗效及其对患者机体免疫功能的影响。方法:临床选取肺腺癌化疗后并发肺部感染患者70例,其中35例为痰热清治疗组,应用痰热清注射液联合抗生素治疗;35例为对照组,单纯注射抗生素治疗。分别对两组病人进行临床观察,并进行相关实验室检查。同时,在用药前后,通过流式细胞术检测患者的外周血T淋巴细胞亚群,并通过银染色法检测患者淋巴细胞中核仁形成区嗜银蛋白含量(AgNORs)的相对含量(I.S)。ELISA法检测患者血清中转化生长因子-β1(TGF-β1)的含量。结果:痰热清治疗组疗效明显优于对照组(P<0.05),且患者外周血T细胞亚群、TGF-β1含量及淋巴细胞I.S值较对照组改善更为明显(P<0.05)。结论:痰热清注射液联合抗生素治疗肺腺癌化疗后并发肺部感染较单独使用抗生素更为有效,同时该药还对患者具有一定的免疫调节作用。
Objective: To observe the effect of Tanreqing injection on patients with pulmonary infection after chemotherapy of lung adenocarcinoma and its influence on the immune function of patients. Methods: Seventy patients with pulmonary infection were selected from clinical lung adenocarcinoma after chemotherapy. Among them, 35 cases were treated with Tanreqing and treated with Tanreqing Injection combined with antibiotics. 35 cases were treated with antibiotics alone. The two groups of patients were clinically observed, and related laboratory tests. At the same time, the peripheral blood T lymphocyte subsets of patients were detected by flow cytometry before and after treatment, and the relative content of AgNORs in nucleolar-forming area of lymphocytes was detected by silver staining (I.S). Serum levels of transforming growth factor-β1 (TGF-β1) were detected by ELISA. Results: Tanreqing treatment group was significantly better than the control group (P <0.05), and T lymphocyte subsets, TGF-β1 content and lymphocyte I.S values in the peripheral blood were significantly improved (P <0.05). Conclusion: Tanreqing injection combined with antibiotics in the treatment of pulmonary adenocarcinoma complicated by pulmonary infection after chemotherapy is more effective than antibiotics alone, while the drug also has some immunomodulatory effects on patients.