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细胞因子白细胞介素 1 β( IL- 1 β)的单核苷酸多态性 ( SNP)在个体间的乙型肝炎疫苗免疫应答多样性中起重要作用。IL- 1 β等位基因 ( + 3953)与疫苗免疫效果有关。 在 92名抗 - HBs阴性志愿者中 ,用聚合酶链反应 -限制性片段长度多态性技术进行基因分型。 IL - 1β( + 39
The single nucleotide polymorphism (SNP) of cytokine interleukin 1 β (IL-1 β) plays an important role in the diversity of the hepatitis B vaccine immune response among individuals. The IL-1 beta allele (+ 3953) is associated with the vaccine’s immunogenicity. In 92 anti-HBs-negative volunteers, genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism. IL - 1β (+39