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目的探讨新生儿窒息后胃动素和一氧化氮的变化及其对肠道菌群的影响。方法选取26例新生儿窒息患儿及26例正常新生儿作为研究对象,分别于生后24～48 h对其血液胃动素和一氧化氮水平进行检测。同时对其粪便进行培养,检测其中双歧杆菌和肠球菌的菌落数量,并分析其与血液胃动素及一氧化氮之间的相关性。结果新生儿窒息患儿在生后24～48 h,其血液胃动素水平明显低于正常新生儿,而血液一氧化氮水平则较正常新生儿存在显著的增高。粪便培养结果显示,新生儿窒息患儿粪便中双歧杆菌和肠球菌所形成的菌落数量均较正常新生儿明显减少,并且其菌落数量与血液胃动素水平之间呈明显的正相关,而与血液一氧化氮水平则呈现负相关。结论新生儿窒息造成了血液胃动素水平的降低和一氧化氮水平的上调,进而显著影响了肠道菌群的定植。
Objective To investigate the changes of motilin and nitric oxide after neonatal asphyxia and their effects on intestinal flora. Methods Twenty-six neonates with asphyxia and 26 normal neonates were enrolled in this study. Their blood motilin and nitric oxide levels were measured at 24-48 h after birth. At the same time, their stools were cultured to detect the number of colonies of Bifidobacteria and enterococci, and their correlation with blood motilin and nitric oxide was analyzed. Results In neonates with asphyxia, the level of blood motilin was significantly lower than that of normal newborns at 24-48 h after birth, while the level of blood nitric oxide was significantly higher than that of normal neonates. Stool culture results showed that the number of colonies formed by bifidobacteria and enterococci in excrement of neonates with asphyxia was significantly lower than that of normal neonates and the number of colony was positively correlated with the level of blood motilin And blood levels of nitric oxide is negatively correlated. Conclusions Neonatal asphyxia causes a decrease in blood motilin level and an increase in nitric oxide levels, which in turn significantly affects the colonization of intestinal flora.