内皮素（ｅｎｄｏｔｈｅｌｉｎ）是由日本学者Ｙａｎａｇｉｓａｗａ等人在１９８８年首先从猪的主动脉内皮细胞培养液中分离并提纯出来的一种具有２１个氨基酸的多肽，是目前已知的最强的血管收缩剂（１），并能促进血管平滑肌细胞增殖，参与肾脏疾病的发生和发展。１内皮... Endothelin (endothelin) is a 21 amino acid peptide isolated and purified from porcine aortic endothelial cell culture by Yanagisawa et al. In 1988. It is the strongest vasoconstrictor known to date Agent (1), and can promote the proliferation of vascular smooth muscle cells involved in the occurrence and development of kidney disease. 1 endothelium