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目的 探讨抑癌基因ｐ２１ 在喉鳞癌中表达情况及其与肿瘤的临床关系。方法 采用免疫组化 Ｌ Ｓ Ａ Ｂ方法对３７ 例喉原发性鳞癌、癌旁１．０ ｃｍ 组织及２０ 例声带息肉行ｐ２１ 检测研究。结果 ｐ２１ 表达定位于胞浆，癌旁组中有３ 例软骨细胞出现胞核阳性。喉癌组与癌旁组及声带息肉组之间表达率差异有显著性（ Ｐ＜ ０．０５）。组织分化高者表达高。结论 ｐ２１ 在喉癌细胞的生长调控中可能起着重要作用。
Objective To investigate the expression of tumor suppressor gene p21 in laryngeal squamous cell carcinoma and its clinical relationship with tumor. Methods 37 cases of primary squamous cell carcinoma of larynx, 1.0 cm of para-cancerous tissue and 20 cases of vocal cord polyps were examined by immunohistochemical L S A B method. Results The expression of p21 was localized in the cytoplasm. In the paracancer group, 3 chondrocytes were positive for nuclei. There were significant differences in the expression rates of laryngocarcinoma group, paracarcinoma group and vocal cord polyp group (P <0.05). High tissue expression of high expression. Conclusion p21 may play an important role in the growth and regulation of laryngeal carcinoma cells.