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目的探讨急性脑梗死患者血清神经元特异性烯醇化酶(NSE)和S-100β蛋白的变化及与急性脑梗死的关系。方法采用酶联免疫吸附法测定80例急性脑梗死患者NSE、S-B100β蛋白及40例健康体检者(对照组)血清NSE和S-100β蛋白含量。结果急性脑梗死患者血清NSE和S-100β蛋白浓度均明显高于对照组,差异有统计学意义(P<0.05),且NSE和S-100β蛋白水平随梗死面积的增大及神经功能缺损程度的加重逐渐升高,差异有统计学意义(P<0.05)。结论血清NSE和S-100β蛋白水平较好地反映了急性脑梗死梗死面积及神经功能缺损程度,可以作为判断急性脑梗死梗死面积、评价疗效和估计预后的一个重要手段。
Objective To investigate the changes of serum neuron-specific enolase (NSE) and S-100β protein in patients with acute cerebral infarction and its relationship with acute cerebral infarction. Methods Serum levels of NSE and S-100β protein in 80 patients with acute cerebral infarction and 40 healthy controls (control group) were determined by enzyme-linked immunosorbent assay. Results Serum concentrations of NSE and S-100β in patients with acute cerebral infarction were significantly higher than those in the control group (P <0.05). The protein levels of NSE and S-100β increased with infarct size and the degree of neurological deficits Increased gradually, the difference was statistically significant (P <0.05). Conclusion The serum levels of NSE and S-100β reflect the infarct size and the degree of neurological deficits well in acute cerebral infarction, which can be used as an important means to judge the infarct size of acute cerebral infarction and evaluate the curative effect and prognosis.