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目的 通过直肠病变脱落细胞超微结构的研究,揭示直肠疾病的病因病理特征。 方法 用砂片指套作指诊,采集18例直肠病变脱落活细胞,按序制作超薄切片染色,电镜下观察拍照。 结果 直肠炎症、腺癌、绒毛状腺瘤及其癌变、恶性黑色素瘤细胞的超微结构各有其特征,在电镜下均可分为亮细胞和暗细胞2种;恶性黑色素瘤细胞内黑色素颗粒在亮细胞多成团分布,在暗细胞多散在分布于细胞边缘;绒毛状腺瘤及其癌变的发生可能和细菌感染有关。 结论 直肠病变脱落细胞超微结构的研究,能更加深入地了解直肠疾病的生物学特征。
Objective To study the ultrastructure of exfoliated cells in rectal lesions and to reveal the etiological and pathological features of rectal diseases. Methods With the fingers of the sand as a fingernail, 18 living cells of rectal lesions were collected, and ultrasonographs were made in sequence. The images were taken under the electron microscope. Results The ultrastructures of rectal inflammation, adenocarcinoma, villous adenoma and their cancerous and malignant melanoma cells all had their own characteristics. Under electron microscope, they could be divided into bright cells and dark cells. The melanin granules in malignant melanoma cells Multi-group distribution in the bright cells, scattered in the dark cells scattered in the cell edge; villous adenoma and carcinogenesis may be related to bacterial infection. Conclusion The study on the ultrastructure of exfoliated cells in rectal lesions can further understand the biological characteristics of rectal diseases.