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目的:基于“脾主运化”理论,探讨结肠黏膜Glu及NO在肠易激综合征发病机制中的作用。方法:给予大鼠反复直结肠灌注中药大黄造成炎症刺激,炎症恢复后,再给予小量电刺激诱发高敏感性的肠道发生应激反应,制备IBS动物模型,观察疏肝健脾法对大鼠结肠黏膜Glu及NO含量的影响。结果:模型组与正常对照组比较,Glu及NO含量明显升高(P<0.01);疏肝健脾组与模型组比较,Glu及NO含量有一定程度减少(P<0.01)。结论:大黄-电刺激大鼠模型可有效制备IBS动物模型;基于“脾主运化”理论的疏肝健脾法能够改善该模型的缺损症状,对IBS有一定的防治作用。
OBJECTIVE: To investigate the role of Glu and NO in colonic mucosa in the pathogenesis of irritable bowel syndrome (IBS) based on the theory of spleen transport. Methods: Rats were given repeated infusion of rhubarb rhubarb inflammation caused by inflammation, inflammation recovery, and then given a small amount of electrical stimulation induced hypersensitivity in the intestinal reaction, prepared animal models of IBS observed Shuganjianpi method of large Effect of Glu and NO Contents in Rat Colon Mucosa. Results: The levels of Glu and NO in model group were significantly higher than those in normal control group (P <0.01). Compared with model group, the content of Glu and NO in Shuganjianpi group decreased to a certain extent (P <0.01). Conclusion: Rhubarb - electrical stimulation rat model can effectively prepare animal models of IBS; based on “spleen main transport ” theory of Shuganjianpi method can improve the model of the defect symptoms of IBS have a preventive effect.