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目的探讨2型糖尿病(T2DM)及合并急性脑梗死患者血清溶血磷脂酸(LPA)、相关磷脂(AP)浓度与胰岛素抵抗(IR)的相关性。方法采用生物化学法测定肘静脉血中LPA、AP浓度并进行相关性分析。结果T2DM合并急性脑梗死组患者血浆LPA及AP浓度显著高于T2DM组和对照组[(4.44±2.30)vs(3.18±1.86)vs(2.27±0.89)μmol/L,(5.53±2.59)vs(3.72±1.59)vs(2.27±0.89)μmol/L],P<0.05;线性相关分析显示血浆LPA、AP浓度与IR程度成正相关(r=0.850、0.482、0.757,P<0.01;r=0.865、0.121、0.679,P<0.01)。结论T2DM及其合并急性脑梗死患者血清LPA和AP含量显著增高,且LPA、AP浓度与胰岛素抵抗程度成正相关。
Objective To investigate the relationship between serum lysophosphatidic acid (LPA), related phospholipid (AP) and insulin resistance (IR) in type 2 diabetes mellitus (T2DM) and patients with acute cerebral infarction. Methods Biochemical methods were used to determine LPA and AP concentrations in the elbow vein and their correlations were analyzed. Results The plasma levels of LPA and AP in patients with T2DM complicated with acute cerebral infarction were significantly higher than those in T2DM patients and controls (4.44 ± 2.30 vs 3.18 ± 1.86 vs 2.27 ± 0.89 μmol / L vs 5.53 ± 2.59 vs 3.72 ± 1.59 vs 2.27 ± 0.89 μmol / L, P <0.05). The linear correlation analysis showed that plasma LPA and AP concentrations were positively correlated with IR (r = 0.850,0.482,0.757, P <0.01; r = 0.865, 0.121,0.679, P <0.01). Conclusions Serum levels of LPA and AP in patients with T2DM and its acute cerebral infarction are significantly increased, and the concentrations of LPA and AP are positively correlated with the degree of insulin resistance.