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目的:探讨新疆地区维吾尔族消化性溃疡并发消化道出血的相关影响因素。方法:随机选取消化性溃疡合并出血及不合并出血的维吾尔族患者各100例。比较两组患者性别、年龄、烟酒史、溃疡部位、非甾体抗炎药服用、幽门螺旋杆菌情况。结果:两组中性别及有烟酒史比例无显著统计学差异,但出血组年龄≥60岁患者的比例显著高于未出血组(P<0.001)。出血组患者胃溃疡比例显著高于未出血组,十二指肠溃疡比例显著低于未出血组(P=0.002)。出血组与未出血组幽门螺旋杆菌阳性患者比例无显著统计学差异(P=0.777),出血组使用非甾体抗炎药患者比例显著高于未出血组(P<0.001)。结论:年龄≥60岁,胃溃疡及非甾体抗炎药的使用是新疆地区维吾尔族消化道溃疡出血的主要原因。
Objective: To investigate the related factors of peptic ulcer complicated with gastrointestinal bleeding in Uygur in Xinjiang. Methods: 100 Uygur patients with peptic ulcer combined with hemorrhage and without hemorrhage were randomly selected. The gender, age, alcohol and tobacco history, ulcer sites, non-steroidal anti-inflammatory drugs and Helicobacter pylori were compared between the two groups. Results: There was no significant difference between the two groups in terms of sex and history of smoking and drinking alcohol. However, the proportion of patients with bleeding ≥ 60 years old was significantly higher than that without bleeding (P <0.001). The proportion of gastric ulcer in bleeding group was significantly higher than that in non-bleeding group, and the proportion of duodenal ulcer was significantly lower in non-bleeding group (P = 0.002). There was no significant difference in the proportion of Helicobacter pylori positive patients between hemorrhage group and non-hemorrhage group (P = 0.777). The proportion of non-steroidal anti-inflammatory drug in bleeding group was significantly higher than that in non-hemorrhagic group (P <0.001). Conclusion: The use of gastric ulcer and non-steroidal anti-inflammatory drugs is the main cause of bleeding in Uygur patients with peptic ulcer in Xinjiang.