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慢性淋巴细胞白血病是一种来源于 B 细胞的恶性单克隆淋巴细胞增生性疾病。晚期患者有血小板减少、贫血、脾肿大及器官浸润者其存活期甚短。一般采用烷化剂及激素进行治疗,有效率达60%。烷化剂治疗无效时,常采用加强联合化疗。但加强化疗毒性相当大,而且反应期亦短。目前尚无标准的二线治疗方法。故寻找新的有效的治疗药物就显得十分重要。本文报道应用新药2-氯去氧腺苷(2-chlorodeoxyad-enosine)对晚期慢性淋巴细胞白血病治疗的经验。方法 18例 B 细胞性晚期慢性淋巴细胞白血病均为对常规治疗有抗药性之病例。以2-氯去氧腺苷0.05～0.2mg/kg/d 加入生理盐水500ml 中,于24h内静脉滴注,7天为一疗程。病人接受1～4个疗程的治疗。18例患者共完成44个疗程.
Chronic lymphocytic leukemia is a malignant monoclonal lymphocytic disease derived from B cells. Patients with advanced thrombocytopenia, anemia, splenomegaly and organ infiltration who have very short survival. Generally used alkylating agents and hormones for treatment, the effective rate of 60%. Alkalis treatment ineffective, often used to strengthen the combination of chemotherapy. However, to enhance the toxicity of chemotherapy is quite large, and the reaction period is also short. There is currently no standard second-line treatment. Therefore, it is very important to find new and effective therapeutic drugs. This article reports the application of a new drug, 2-chlorodeoxyad-enosine, in the treatment of advanced chronic lymphocytic leukemia. Methods 18 cases of B-cell chronic lymphocytic leukemia are routine treatment resistant cases. To 2-chloro-deoxyadenosine 0.05 ~ 0.2mg / kg / d added 500ml of normal saline, intravenous infusion within 24h, 7 days for a course of treatment. Patients receive 1 to 4 courses of treatment. 18 patients completed a total of 44 courses.