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利福平作为一种超广谱半合成抗生素,以其高效、低毒、可口服等优点,已越来越广泛地运用于结核病的治疗中.利福平副作用之一的胃肠反应通常为厌食、恶心、腹部轻度不适或疼痛,腹泻虽也可发生,但不多见,现报告一例如下:患者女,35岁.以腹胀、乏力、盗汗、食欲下降一年半为主诉就医.病人一年半前因上述病情考虑为结核病,自服异烟肼一日三次,两次0.1克,连服5个月后症状未减轻,自行停药.一年前患者出现消瘦、腹胀、盗汗、右下腹疼、便秘腹泻交替出现,经省级医院检查诊断为肠结核,开始常规用药治疗(每日肌注链霉素0.75克,口服异烟肼0.3克,乙胺丁醇1.0克)并半日休息.一个月后自觉症状好转,因链霉素引起眩晕而停用,换成利福平每日0.45克空腹口服.三个月前腹部症状减轻,随即将常规疗法改为
As a kind of extended-spectrum semi-synthetic antibiotics, rifampicin has been used more and more widely in the treatment of tuberculosis with its advantages of high efficiency, low toxicity and oral administration, etc. One of the side effects of rifampicin is gastrointestinal reaction Anorexia, nausea, mild abdominal discomfort or pain, although diarrhea may occur, but rare, a report is as follows: Female patients, aged 35 to bloating, fatigue, night sweats, loss of appetite for a year and a half mainly for medical treatment. A year and a half ago because of the above conditions considered as tuberculosis, self-service isoniazid three times a day, two times 0.1 grams, and even served 5 months after the symptoms did not alleviate their own withdrawal.A year ago, patients wasting, bloating, night sweats, Right lower quadrant pain, constipation and diarrhea alternately appear, diagnosed by the provincial hospital as intestinal tuberculosis, began routine treatment (daily intramuscular streptomycin 0.75 g, oral isoniazid 0.3 g, ethambutol 1.0 g) and half a day Rest. A month later symptoms improved, dizzy due to streptomycin dizzy, replaced rifampicin daily 0.45 g fasting oral .3 months ago, reduce the symptoms of the abdomen, then the conventional therapy to