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目的研究内皮细胞生长因子(vascular endothelial growth factor,VEGF)与胃泌素(Gastrin,GAS)在胃癌中的表达以及与临床病理特征的关系。方法采用免疫组化法检测VEGF、GAS在胃癌中的表达,采用统计学方法分析其与临床病理特征的关系。结果免疫组化法检测胃癌组织VEGF阳性率为62.7%(79/126),GAS阳性率为72.2%(91/126)。其中VEGF的表达与淋巴结转移相关(P<0.05),GAS的表达与肿瘤患者幽门螺杆菌(Helicobacter pylori,Hp)感染有关。结论 GAS可能参与Hp阳性胃癌患者的肿瘤发生,而VEGF可能促进胃癌肿瘤的淋巴结转移。
Objective To study the expression of endothelial cell growth factor (VEGF) and gastrin (GAS) in gastric cancer and its relationship with clinicopathological features. Methods Immunohistochemical method was used to detect the expression of VEGF and GAS in gastric cancer. The relationship between the expression of VEGF and GAS and the clinicopathological features was analyzed by statistical methods. Results The positive rate of VEGF in gastric cancer tissues was 62.7% (79/126), and the positive rate of GAS was 72.2% (91/126). The expression of VEGF was correlated with lymph node metastasis (P<0.05). The expression of GAS was related to Helicobacter pylori (Hp) infection in cancer patients. Conclusion GAS may participate in the tumorigenesis of Hp-positive gastric cancer patients, while VEGF may promote the lymph node metastasis of gastric cancer tumors.