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目的研究西洋参叶20s-原人参二醇组皂苷(Panaxquinquefolium20s-protopanaxdiolsaponins,PQDS)对大鼠实验性心室重构的防治作用。方法大鼠结扎左冠状动脉前降支4周造成心肌梗死后心室重构模型,同时应用PQDS进行治疗,给药4周后测定心室重构大鼠的心脏形态学、血流动力学及生物化学等参数。结果ipPQDS25~100mg.kg-1,对心室重构大鼠,能明显升高左心室内压最大上升和下降速率(±dp/dtmax)及其校正值[±dp/dtmax)/LVSP],降低左心室舒张末压(LVEDP),亦能明显降低左心室容积(LVV)、左心室长轴(LVLA)长度、左心室短轴(LVSA)长度、左心室绝对重量(LVAW)、左心室相对重量(LVRW),但对右心室绝对重量(RVAW)、右心室相对重量(RVRW)、心率(HR)、左心室收缩压(LVSP)、平均动脉压(MAP)及体重(BW)均无明显影响。此外,PQDS可明显降低血清脂质过氧化物(LPO)及心肌血管紧张素Ⅱ(AngⅡ)和肾上腺素(E)含量,提高超氧化物歧化酶(SOD)、过氧化氢酶(CAT)及谷胱甘肽过氧化物酶(GSH-Px)活性。结论PQDS能有效防治大鼠心肌梗死后的心室重构。可能与抑制心脏局部AngⅡ生成和抑制交感神经末梢释放CA以及提高心肌的抗氧化能力有关。
Objective To study the preventive and therapeutic effects of panaxquinquefolium 20s-protopanaxdiolsaponins (PQDS) on experimental ventricular remodeling in rats. METHODS: After ligating the left anterior descending coronary artery for 4 weeks, the rat model of ventricular remodeling after myocardial infarction was established and treated with PQDS. The cardiac morphometry, hemodynamics and biochemistry of ventricular remodeling rats were determined 4 weeks after administration. And other parameters. RESULTS: ipPQDS25~100mg.kg-1 could significantly increase the maximum increase and decrease rate of left ventricular pressure (±dp/dtmax) and its correction value [±dp/dtmax)/LVSP] in ventricular remodeling rats, and decreased Left ventricular end-diastolic pressure (LVEDP) can also significantly reduce left ventricular volume (LVV), left ventricular long axis (LVLA) length, left ventricular short axis (LVSA) length, left ventricular absolute weight (LVAW), and left ventricular relative weight (LVRW), but no significant effect on right ventricular absolute weight (RVAW), right ventricular relative weight (RVRW), heart rate (HR), left ventricular systolic pressure (LVSP), mean arterial pressure (MAP) and body weight (BW) . In addition, PQDS can significantly reduce serum lipid peroxide (LPO) levels, myocardial angiotensin II (AngII) and epinephrine (E) levels, and increase superoxide dismutase (SOD), catalase (CAT) and Glutathione peroxidase (GSH-Px) activity. Conclusion PQDS can effectively prevent ventricular remodeling after myocardial infarction in rats. It may be related to inhibiting the local production of AngII in the heart and inhibiting the release of CA from sympathetic nerve endings and improving the antioxidant capacity of the myocardium.