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目的探讨血浆内源性硫化氢(H_2S)在支气管哮喘患儿病程中的表达及其与肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)的相关性。方法选择60名急性发作期哮喘患儿及30名健康体检儿童,检测血浆H_2S、TNF-α及IL-6的表达水平并随访,比较哮喘患儿急性发作期、慢性持续期及临床缓解期血浆H_2S、TNF-α及IL-6表达水平的差异,并分析H_2S与TNF-α及IL-6的相关性。结果支气管哮喘患儿病程各期血浆H_2S水平低于健康儿童,TNF-α及IL-6水平高于健康儿童。急性发作期H_2S水平低于慢性持续期,慢性持续期低于临床缓解期;急性发作期TNF-α及IL-6水平高于慢性持续期,慢性持续期高于临床缓解期。相关分析结果显示:哮喘患儿血浆H_2S水平同TNF-α及IL-6水平呈负相关。结论支气管哮喘患儿血浆内源性H_2S表达水平降低,随病情控制逐渐回升,并且和TNF-α及IL-6水平负相关,可在一定程度上作为哮喘控制情况的评价指标。
Objective To investigate the expression of plasma endogenous hydrogen sulfide (H 2 S) in the course of the disease in children with bronchial asthma and its relationship with tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6). Methods Sixty children with acute exacerbation of asthma and 30 healthy children were enrolled in this study. The plasma levels of H 2 S, TNF-α and IL-6 were detected and followed up. The levels of plasma and plasma levels of acute and chronic asthmatic children H 2 S, TNF-α and IL-6, and analyzed the correlation between H 2 S, TNF-α and IL-6. Results The levels of plasma H 2 S in children with bronchial asthma at different stages were lower than those in healthy children, and the levels of TNF-α and IL-6 were higher than those in healthy children. The levels of H 2 S in acute episodes were lower than those in chronic ones, and those in chronic phases were lower than those in clinical remission. The levels of TNF-α and IL-6 in acute episodes were higher than those in chronic ones, and those in chronic phases were higher than those in patients in clinical remission. Correlation analysis showed that plasma H 2 S levels in children with asthma were negatively correlated with TNF-α and IL-6 levels. Conclusion The expression of endogenous H 2 S in children with bronchial asthma is decreased, and gradually rises with the control of the disease, and negatively correlated with the levels of TNF-α and IL-6, which may be used as an evaluation indicator for the control of asthma.