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目的观察硝苯地平联合硫酸镁治疗妊娠高血压疾病的临床疗效。方法选取礼泉县民源医院收治的妊娠高血压疾病患者中符合标准的100例患者做为研究对象,分为观察组和对照组各50例。对照组给予硫酸镁静脉滴注治疗,观察组在给予硫酸镁静脉滴注治疗的基础上联合口服硝苯地平进行治疗,观察两组治疗后的临床效果。检测患者收缩压和舒张压,比较治疗前后的变化情况;测量两组患者治疗前后尿蛋白水平、血黏度、红细胞压积(PCV)、胎儿脐动脉收缩压与舒张压的比值(S/D)、C反应蛋白(CPR)及CD4+/CD8+变化情况。对两组患者治疗后进行追踪预后,比较产妇及新生儿结局:终止妊娠、自然分娩、早产、新生儿窒息的发生率。结果观察组总有效率为94%,明显高于对照组总有效率74%(P<0.05);治疗后两组患者血压较治疗前有明显降低(P<0.05);观察组比对照组降低更明显,组间比较差异具有统计学意义(P<0.05)。治疗后两组尿蛋白水平均显著下降(P<0.05);观察组尿蛋白水平明显低于对照组(P<0.05)。治疗后两组患者血黏度、PCV、S/D、CPR及CD4+/CD8+都明显改善,与治疗前比较差异显著(P<0.05),且观察组各指标改善情况明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,观察组患者自然分娩率明显高于对照组患者,观察组产妇终止妊娠、早产及新生儿窒息的发生率明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论硝苯地平联合硫酸美治疗妊娠高血压疗效明显,具有临床推广价值。
Objective To observe the clinical efficacy of nifedipine combined with magnesium sulfate in the treatment of pregnancy induced hypertension. Methods 100 cases of pregnancy-induced hypertension patients admitted to Liyuan County People’s Hospital were selected as the research object and divided into observation group and control group with 50 cases each. The control group was treated with intravenous infusion of magnesium sulfate. The observation group was treated with intravenous drip of magnesium sulfate and oral nifedipine. The clinical effects of the two groups were observed. The systolic blood pressure and diastolic blood pressure were measured to compare the changes before and after treatment. Urine protein level, blood viscosity, hematocrit (PCV), fetal umbilical artery systolic pressure and diastolic blood pressure (S / D) , C-reactive protein (CPR) and CD4 + / CD8 + changes. Two groups of patients were followed up after treatment prognosis, maternal and neonatal outcomes compared: termination of pregnancy, spontaneous delivery, premature birth, neonatal asphyxia incidence. Results The total effective rate was 94% in the observation group, which was significantly higher than 74% in the control group (P <0.05). After treatment, the blood pressure of the two groups was significantly lower than that before treatment (P <0.05) More obviously, the difference between the groups was statistically significant (P <0.05). After treatment, the urinary protein levels in both groups were significantly decreased (P <0.05); the urinary protein level in the observation group was significantly lower than that in the control group (P <0.05). After treatment, the blood viscosity, PCV, S / D, CPR and CD4 + / CD8 + in both groups were significantly improved (P <0.05), and the improvement of each index in the observation group was obviously better than that in the control group The difference was statistically significant (P <0.05). After treatment, the spontaneous delivery rate of observation group was significantly higher than that of control group. The incidence of termination of pregnancy, premature birth and neonatal asphyxia in observation group was significantly lower than that in control group. There was significant difference between the two groups (P <0.05). Conclusion Nifedipine combined with sulphate is effective in treating pregnancy-induced hypertension and has clinical value of popularization.