The lighting system accounts for 8％ of the total electricity consumption in commercial buildings in the United States and 12％ of the total electricity consumption in public buildings globally. This consumption share can be effectively reduced using the demand-response control. The traditional lighting system control method commonly depends on the real-time occupancy data collected using the passive infrared (PIR) sensor. However, the detection inaccuracy of the PIR sensor usually results in false-offs. To diminish the false-error frequency, the existing lighting system control simply deploys a delayed reaction period (e.g., 5 to 20 min), which is not sufficiently accurate for the demand-response operation. Therefore, in this research, a novel data-driven model predictive control (MPC) method that is based on the temporal sequential-based artificial neural network (TS-ANN) is proposed to overcome this challenge using an updated historical occupancy status. Using an office as case study, the proposed model is also compared with the traditional lighting system control method. In the proposed model, the occupancy data was trained to predict the occupancy pattern to improve the control. It was found that the occupancy prediction mainly correlates with the historical occupancy ratio and the time sequential feature. The simulation results indicated that the proposed method achieved higher accuracy (97.4％) and fewer false-offs (from 79.5 with traditional time delay method to 0.6 times per day) are achieved by the MPC model. The proposed TS-ANN-MPC method integrates the analysis of the occupant behavior routine into on-site control and has the potential to further enhance the control performance practice for maximum energy conservation.