PTEN是1997年发现的第一个具有磷酸酶活性的抑癌基因,其缺失、突变和表达减少广泛存在于多种进展期肿瘤中,核内外的PTEN通过细胞凋亡和诱导细胞周期停滞抑制肿瘤的发生发展。最近研究发现,PTEN可以通过泛素化进入细胞核内,并通过诱导细胞周期停滞和维持染色体完整性在核内起到肿瘤抑制作用。本文就PTEN的核转位及其在核内的多种功能作一综述。 PTEN is the first tumor suppressor gene with phosphatase activity discovered in 1997. The deletion, mutation and expression of PTEN are widespread in many advanced tumors. PTEN inhibits tumor through apoptosis and induces cell cycle arrest The occurrence and development. Recent studies have found that PTEN can enter the nucleus through ubiquitination and act as a tumor suppressor in the nucleus by inducing cell cycle arrest and maintaining chromosomal integrity. This review summarizes the nuclear translocation of PTEN and its multiple functions in the nucleus.