一、前言皮肤烧伤特别是深度和大面积烧伤经常需要植皮治疗。自体皮片不存在免疫排斥、不传播疾病、愈合能力强,其优点不言而喻。缺点是自体取皮常受到数量和时间的限制,因此同种植片(例如人类尸体皮肤和胎盘羊膜),异种植片(例如猪皮)以及皮肤代用品的开发利用受到重视。由于同种和异种植片不能克服免疫排斥,即便使用有活力的组织也不可能长期存活,它们和皮肤代用品一样只能起到暂时性生物敷料的作用,目 I. INTRODUCTION Skin burns, especially deep and large burns, often require skin grafting. Autologous skin does not have immune rejection, does not spread disease, and has a strong healing capacity. Its advantages are self-evident. The disadvantage is that autologous skin grafting is often limited by the amount and time, so the development and use of implanted tablets (such as human cadaver skin and placental amnion), heteroimplanted tablets (eg, pigskin), and skin substitutes are valued. Since allograft and heterograft tablets cannot overcome immune rejection, it is impossible to survive long-term survival even with viable tissue. They can only serve as temporary biologic dressings as skin substitutes.