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目的:研究维拉帕米(verapamil)对人类海绵体组织的体外舒张作用,评价其对勃起功能障碍(ED)的潜在治疗作用。方法:从刚死亡的勃起功能正常的年轻男性身上取用海绵体组织,用10 mmol/L 苯福林诱导组织收缩,用不同剂量维拉帕米降低组织收缩,记录等长张力及其详细弯曲度,无菌水作为对照。用加入维拉帕米或无菌水之前最高张力的百分比表示海绵体组织制备品的张力,统计方法为 ANOVA 和最小显著差法。结果:用药30分钟后,1 μmol/L,10 μmol/L 和100 μmol/L 维拉帕米的舒张作用分别为35.28%±7.96%,(55.91±6.41)%和(85.68±4.16)%。对照组在同一时间点的舒张作用为(-0.06±10.57)(P<0.05)。结论:维拉帕米在体外对由苯福林诱导的正常人类海绵体平滑肌的舒张作用十分显著,这种舒张作用有浓度依赖性。
Objective: To study the in vitro diastolic function of verapamil on human cavernous tissues and to evaluate its potential therapeutic effect on erectile dysfunction (ED). Methods: Cavernous tissues were obtained from the newly euthanized normal male. The tissue was induced with 10 mmol / L phenylephrine and the tissue contracted with different doses of verapamil. The isometric tension and its detailed bending were recorded Degree, sterile water as a control. Tissue of the cavernous tissue was expressed as a percentage of the highest tension prior to the addition of verapamil or sterile water. The statistical methods were ANOVA and Minimal Significant Difference. Results: The diastolic effects of verapamil were 35.28% ± 7.96%, (55.91 ± 6.41)% and (85.68 ± 4.16)%, respectively, at 1 μmol / L, 10 μmol / L and 100 μmol / L after 30 minutes. The diastolic effect of the control group at the same time point was (-0.06 ± 10.57) (P <0.05). CONCLUSION: Verapamil has a very significant relaxation effect on normal human sponge smooth muscle induced by phenylephrine in vitro in a concentration-dependent manner.