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盐酸西那卡塞是第一个上市的拟钙剂类药物,能有效降低甲状旁腺激素的过量分泌,并有助于降低血清钙和血清磷。临床上,西那卡塞常用于治疗慢性肾脏病患者的继发性甲状旁腺功能亢进,也用于原发性甲状旁腺功能亢进的高钙血症或肾移植患者的持续性甲状旁腺功能亢进。本文主要对盐酸西那卡塞的基本概况和临床应用等做一综述,希望对西那卡塞的临床研究和进一步应用提供帮助。
Cinacalcet hydrochloride is the first commercially available calcimimetic that effectively reduces parathyroid hormone overdose and helps to lower serum calcium and serum phosphorus. Clinically, cinacalcet is commonly used in the treatment of secondary hyperparathyroidism in patients with CKD and in persistent hyperparathyroidism or persistent parathyroid gland in patients with primary hyperparathyroidism Functional hyperthyroidism. This article mainly summarizes the basic situation and clinical application of cinacalcet hydrochloride and so on, hoping to help clinical research and further application of cinacalcet.