论文部分内容阅读
已证实α-干扰素治疗成人慢性丙型肝炎有效,ALT复常率在40～70％,而且停止治疗后ALT正常者仍有10～30％,儿童丙型肝炎虽少见,也可考虑用抗病毒治疗。近期的一项非对照试验已显示α-干扰素治疗儿童慢性丙型肝炎6个月后(一疗程)有相当比例患儿ALT恢复正常,具有良好的耐受性。因此,作者进行了小规模的随机对照研究以评价重组α-干扰素12个月一疗程治疗儿童慢性丙型肝炎的效果。 1991年4月至1992年6月,对27例慢性丙型肝炎患儿(年龄2～14岁)进行研究。ALT异常6个月以上,治疗前1年内肝活检显示19例为慢性活动性肝炎,8例为慢性迁延性肝炎。HCV RNA阳性22例。随机对照试验分两组,治疗组14例,用重组α-2b干扰素5MU/m~2,每周3次,连用4个月,如ALT下降50％以上者治疗延续到12个月。对照组13例未用干扰素。
Alpha-interferon has been shown to be effective in treating chronic hepatitis C in adults with an ALT normalization rate of 40-70% and an ALT level of 10-30% after discontinuation of treatment. Although hepatitis C is rare in children, Virus treatment. A recent non-controlled trial of α-interferon in children with chronic hepatitis C after 6 months (a course of treatment) has shown that a significant proportion of children with normal ALT return have good tolerability. Therefore, the authors conducted a small-scale randomized controlled study to evaluate the effect of recombinant IFN-α for 12 months on a course of treatment for chronic hepatitis C in children. From April 1991 to June 1992, 27 children with chronic hepatitis C (aged 2-14 years) were studied. ALT abnormalities more than 6 months, 1 year before treatment liver biopsy showed 19 cases of chronic active hepatitis, 8 cases of chronic persistent hepatitis. 22 cases were positive for HCV RNA. Randomized controlled trials were divided into two groups, the treatment group of 14 patients with recombinant α-2b interferon 5MU / m 2, 3 times a week, once every 4 months, such as ALT decreased more than 50% of the treatment continued to 12 months. The control group of 13 patients without interferon.