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Objective:To investigatetheclinicalsignificanceof tumornecrosisfactorreceptor-p55(TNFR-p55)expression anditsrelationshipwiththeclinicalpathologyandDukes’classificationof humancolorectalcancer.Methods:SABCimmuno-histochemistrymethodwasusedto examineTNFR-p55expressionin91specimensof colorectalcancer,81surroundingmu-cosasof thetumorsand13normaltissues.Results:TNFR-p55expressionincolorectalcancerwas significantlyhigher than thatinthesurroundingmucosaandnormaltissues,anditwassignificantlyhigherinthesurroundingmucosathaninnormal tissue.TNFR-p55was inverselycorrelatedto serousmembraneinvasionandlymphnodemetastasisof colorectalcancers.TNFR-p55expressioninDukes’A andB stageswassignificantlyhigherthanthatof C stage.Conclu sion:TNFR-p55expres-sionwasimportantto determinethedegreeof malignancyandassessinvasiondepth,lymphnodemetastasisandDukes’clas-sificationincolorectalcancer.
Objective: To investigatetheclinicalsignificanceof tumornecrosisfactorreceptor-p55 (TNFR-p55) expression anditsrelationshipwiththeclinicalpathologyandDukes’classificationof humancolorectalcancer.Methods: SABCimmuno-histochemistrymethodwasusedto examineTNFR-p55expressionin91specimensof colorectalcancer, 81surroundingmu-cosasof thetumorsand13normaltissues.Results: TNFR-p55expressionincolorectalcancerwas significantlyhigher than thatinthesurroundingmucosaandnormaltissues, anditwassignificantlyhigherinthesurroundingmucosathaninnormal tissue.TNFR-p55was inverselycorrelatedto serousmembraneinvasionandlymphnodemetastasisof colorectalcancers.TNFR-p55expressioninDukes’A and B stageswassignificantlyhigherthanthatofC stage.Conclu sion:TNFR-p55expres-sionwasimportantto determinethedegreeof malignancyandassessinvasiondepth, lymphnodemetastasisandDukes’clas-sificationincolorectalcancer.